Sameera Reddy made her debut in Maine Dil Tujhko Diya in 2002. She is famous for her role in Musafir. Sameera failed to give big blockbuster successes like Deepika Padukone or like Konkana Sen Sharma who managed to make their mark in Bollywood, however small through their first few films. However luck favoured Sameera in the South Indian Tamil Cinema where she recently acted in a movie Vaaranam Aayiram directed by Gautham Menon which proved to be a hit.

Now she is doing "Asal" with Ultimate star Ajith